Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.
作者:
Janneke P,van Wijngaarden [1]
;
Karin M A,Swart [1]
;
Anke W,Enneman [1]
;
Rosalie A M,Dhonukshe-Rutten [1]
;
Suzanne C,van Dijk [1]
;
Annelies C,Ham [1]
;
Elske M,Brouwer-Brolsma [1]
;
Nikita L,van der Zwaluw [1]
;
Evelien,Sohl [1]
;
Joyce B J,van Meurs [1]
;
M Carola,Zillikens [1]
;
Natasja M,van Schoor [1]
;
Nathalie,van der Velde [1]
;
Johannes,Brug [1]
;
André G,Uitterlinden [1]
;
Paul,Lips [1]
;
Lisette C P G M,de Groot [1]
作者单位:
From the Division of Human Nutrition, Wageningen University, Wageningen, Netherlands (JPvW, RAMD-R, EMB-B, NLvdZ, and LCPGMdG); the Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research (KMAS, ES, NMvS, JB, and PL) and the Department of Internal Medicine, Endocrine Section (PL), VU University Medical Center, Amsterdam, The Netherlands; the Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands (AWE, SCvD, ACH, JBJvM, MCZ, NvdV, and AGU); and the Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, The Netherlands (NvdV).
[1]
主题词:
老年人(Aged);老年人, 80以上(Aged, 80 and over);营养保健品(Dietary Supplements);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);终点测定(Endpoint Determination);女(雌)性(Female);叶酸(Folic Acid);随访研究(Follow-Up Studies);高半胱氨酸(Homocysteine);人类(Humans);高同种半胱氨酸血症(Hyperhomocysteinemia);发病率(Incidence);男(雄)性(Male);运动活动(Motor Activity);荷兰(Netherlands);骨质疏松性骨折(Osteoporotic Fractures);危险因素(Risk Factors);治疗结果(Treatment Outcome);维生素B12(Vitamin B 12)
DOI:
10.3945/ajcn.114.090043
PMID:
25411293
发布时间:
2023-03-18
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