胰高血糖素样肽-1受体激动剂对中枢神经系统的作用
Effects of glucagon-like peptide-1 receptor agonists on the central nervous system
胰高血糖素样肽-1受体(GLP-1R)激动剂通过GLP-1R刺激胰岛素分泌并改善胰岛细胞的状态,现已成为糖尿病领域研究热点.已证实GLP-1R在中枢神经系统有广泛表达,中枢应用GLP-1R激动剂后其可发挥保护神经细胞、调节食欲、调节认知功能等一系列作用,体现了其在中枢神经系统应用的潜质与价值.
更多Agonist of glucagon-like peptide-I receptor( GLP-1 R)can stimulate insulin secretion and improve the physiological state of islet cells effectively though binding its receptor. It has become a hot topic of diabetes. Studies have shown that GLP-I R was widely expressed in the central nervous system. Agonist of GLP-IR may play some effects in the central nervous system, such as protection of nerve cell, regulation of appetite, influence of cognitive function, etc. These can reflect its potential applications and value.
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