高胰岛素血症:因还是果?
Hyperinsulinemia: cause or consequence
2011年美国糖尿病协会(ADA)年会Banting科学成就奖获得者为波士顿大学的Barbara E.Corkey.她提出2型糖尿病的先决原因是高胰岛素血症,而胰岛素抵抗是其后的代偿.基础胰岛素分泌过剩的原因在于环境因素.其提出2型糖尿病的发病模型是:环境因素造成了高基础胰岛素血症.而环境因素导致胰岛素分泌过剩的共同路径是氧化还原反应的紊乱.
更多The Banting Lecture of American Diabetes Association (ADA) annual meeting in 2011 was delivered by Barbara E.Corkey of Boston University.She believes that the root cause of type 2 diabetes is hyperinsulinemia,and then insulin resistance as compensation.The cause of excess insulin secretion is something in the environment.Her proposed model for type 2 diabetes is:basal hyperinsulinemia caused by environmental background.Her investigations have caused her to hypothesize that the common path leading from these environmental agents to secretion of excess insulin is redox perturbations.
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