胰岛素与内皮细胞功能研究进展
Relationship between insulin and endothelial function
胰岛素作为一个重要的代谢调节激素,还具有保护血管内皮细胞的作用,其作用机制可能为:调节血管内皮因子,抑制内皮细胞的收缩、增强内皮细胞间的紧密连接,防止动脉粥样硬化,调节内皮细胞的生长及活性氧簇(ROS)的表达.因此,胰岛素抵抗和高胰岛素血症导致的胰岛素信号紊乱将减弱胰岛素对内皮细胞的保护作用.然而,胰岛素是否可以成为糖尿病、肥胖等代谢性疾病慢性血管并发症的治疗药物,有待进一步研究.
更多Insulin,as an important hormone of metabolic regulation,can exert beneficial effects on endothelial protection.Mechanisms of endothelial protection include regulating vascular endothelial media-tors,inactivating the endothelial contraction and enhancing cell-cell adhesions,inhibiting atherosclerosis,reg-ulating the growth of endothelial cells,and the expression of reactive oxygen species (ROS).Disturbance of insulin signaling induced by insulin resistance and hyperinsulinemia will impair its effects on endothelial protection.However,whether insulin can be used as a therapy for chronic vascular complications in metabolic diseases such as diabetes,obesity needs further study.
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