早期生长反应因子-1与糖尿病肾病
Early growth response factor-1 and diabetic nephropathy
早期生长反应因子-1(Egr-1)是一种具有锌指结构的转录因子,能被多种刺激因素诱导,并能调控下游多种基因的表达,参与细胞的生长、分化、增殖和凋亡.研究发现,高血糖可引起肾脏Egr-1表达增加,促进系膜细胞增殖、血管内皮功能损伤、细胞外基质积聚、转化生长因子-β过表达和肾纤维化,表明Egr-1与糖尿病肾病的发生、发展密切相关.
更多Early growth response factor-1 (Egr-1) is a zinc finger transcription factor,which can be induced by a variety of stimulus and can also regulate the expression of multiple downstream genes.Egr-1 involves in cell growth,differentiation,proliferation and apoptosis.Studies have found that hyperglycemia can lead to an increase of Egr-1 expression which contributes to mesangial cells proliferation,endothelial dysfunction,extracellular matrix accumulating,overexpression of transformation growth factor-β and renal fibrosis.Therefore Egr-1 is closely related to the development and progression of diabetic nephropathy.
More- 浏览:208
- 被引:5
- 下载:132
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文