重视野生型胃肠间质瘤的诊断与治疗
Diagnosis and treatment of wild-type gastrointestinal stromal tumors
胃肠间质瘤是胃肠道最常见的间叶源性肿瘤, c-kit基因或PDGFRA基因的功能获得性突变是其最重要的特征。有10%~15%的胃肠间质瘤不存在 c-kit 基因及 PDGFRA基因的突变,称为野生型胃肠间质瘤。这一类胃肠间质瘤在分子机制及临床特征上与突变型胃肠间质瘤有显著差异,且其本身存在高度异质性。临床医师在诊断与治疗野生型胃肠间质瘤时应当引起足够的重视。
更多Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and are mostly characterized by c-kit or PDGFRA gain-of-function mutation . About 10%-15% of GIST do not harbor any mutations in the c-kit and PDGFRA genes and are defined as wild-type GIST. There are significant differences in molecular mechanism and clinical characteristics between wild-type GIST and mutant GIST. Wild-type GIST should be considered as a family of diseases due to their extreme heterogeneity. Clinician should pay close attention to the diagnosis and treatment of wild-type GIST.
More- 浏览:644
- 被引:12
- 下载:416
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文