PPARγ和糖皮质激素受体对肝细胞糖代谢的影响
Effect of PPARγ and glucocorticoid receptor on hepatic glucose metabolism
以地塞米松、糖皮质激素受体(GR)阻断剂RU486和吡格列酮孵育HepG2细胞24或48h,测定培养液中的葡萄糖浓度.结果显示,48h时10 mol/L RU486阻断地塞米松的升糖作用,但RU486+吡格列酮组较吡格列酮组培养液中葡萄糖浓度升高(P<0.05),提示PPARγ和GR在肝细胞糖代谢方面可能存在相互作用.
更多HepG2 cells were incubated with dexamethasone,glucocorticoid receptor (GR) antagonist RU486,and pioglitazone for 24 or 48 h.Glucose concentration in culture medium was detected.The results showed that 10 μmol/L RU486 blocked the surge of glucose concentration by 48 h of dexamethasone treatment and the glucose concentration in RU486 + pioglitazone group was higher than pioglitazone group( P<0.05 ),suggesting that the cross talk between PPARγ and GR may exist in hepatic glucose metabolism.
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