2型糖尿病和肥胖的新希望:Irisin
Irisin: a new hope for type 2 diabetes and obesity
运动可改善糖尿病和肥胖等代谢性疾病的机制一直不甚明了,直到肌肉组织分泌的一种新激素Irisin被发现.目前的研究已表明,Irisin可以促进脂肪组织消耗能量,降低体重,并减轻饮食诱发的胰岛素抵抗,改善血糖.耐力运动可以明显增加血浆中Irisin水平,这也表明运动与代谢之间存在明确的联系.鉴于其对肥胖和胰岛素抵抗的作用,Irisin有可能用于治疗肥胖和2型糖尿病.
更多The mechanisms underlying the therapeutic effects of exercise on obesity and type 2 diabetes remained unknown until irisin,a novel hormone secreted from muscle tissue,was identified.Irisin increases total energy expenditure,reduces body weight,and mitigates diet-induced insulin resistance,thus improving glycemic control.Interestingly,the concentration of irisin increases significantly after endurance exercise,suggesting there is an association between exercise and metabolism.Given its antiobesity and antidiabetic effects,irisin has been postulated to serve as an injectable treatment for metabolic disease including obesity and type 2 diabetes.
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