成纤维细胞生长因子21与2型糖尿病合并非酒精性脂肪肝关系的研究
Relationship between FGF-21 and type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease
采用酶联免疫吸附法检测2型糖尿病合并非酒精性脂肪肝(NAFLD)患者血中成纤维细胞生长因子21(FGF-21)水平,结果显示,2型糖尿病合并NAFLD患者的血清FGF-21水平高于单纯2型糖尿病患者[(266.55 ±21.24对220.32±22.68)ng/L,P<0.01],且2组均高于正常对照组[(173.52±16.18)ng/L,P<0.01].血清FGF-21水平与腰围、血糖、甘油三酯等呈正相关.FGF-21可能在2型糖尿病患者合并非酒精性脂肪肝的发生发展中发挥作用.
更多The level of serum fibroblast growth factor-21 (FGF-21) in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease (NAFLD) was determined by ELISA.The results showed that serum FGF-21 level in these patients was higher than that in type 2 diabetic patients [(266.55 ± 21.24 vs 220.32 ± 22.68) ng/L,P< 0.01].Serum FGF-21 levels in both groups were significantly higher than that in normal control group [(173.52 ± 16.18) ng/L,P<0.01].Serum FGF-21 level was positively correlated with waist circumference,blood glucose,and triglyceride.FGF-21 may contribute to the development of NAFLD in the patients with type 2 diabetes mellitus.
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