1型糖尿病中miRNA与免疫调控的相关性及其研究进展
Correlation between immune regulation and miRNAs in type 1 diabetes
1型糖尿病是T细胞介导的自身免疫性疾病,发病机制尚未完全阐明.微小RNA(miRNA)是一种非编码单链RNA,近年来研究发现,miRNA对免疫系统基因表达的调控起到关键作用,Dicer酶或者miRNA异常都可能引起自身免疫反应,从而发生1型糖尿病,其有望成为1型糖尿病早期诊断和治疗的靶点.本文就目前已知的miRNA与1型糖尿病免疫调控的相关性及其研究进展作一综述.
更多It is well established that type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease.Controversial data exist regarding the differential control of the immune system in TI DM.Recent studies have demonstrated that MicroRNAs (miRNAs),single-stranded noncoding RNAs,may play a key role in regulation of gene expression in the immune system.Dicer enzymes or abnormal miRNAs may lead to autoimmune reactions,and thus is expected to become a target for early diagnosis and treatment of T1DM in the future.This article reviews the correlations of known miRNAs with the immune regulation in T1DM and the research progression.
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