骨化三醇治疗对2型糖尿病亚临床大血管病变的影响
Effect of calcitriol on subclinical macrovascular disease in type 2 diabetic patients
观察维生素D水平降低(<30 ng/ml)伴亚临床大血管病变的2型糖尿病患者使用骨化三醇治疗12个月后颈动脉内中膜厚度(cIMT)变化.86例患者分为治疗组(A组,n=44)与对照组(B组,n=42),A组使用骨化三醇干预(0.5 μg/d),2组各40例完成随访.干预后,A组与B组比较,超敏C反应蛋白、可溶性CD36及cIMT显著降低,25-羟维生素D与踝肱指数显著升高(P<0.05).骨化三醇可改善维生素D缺乏的2型糖尿病伴亚临床大血管病变患者的cIMT.
更多The changes of carotid intima media thickness (cIMT) in type 2 diabetic patients with vitamin D insufficiency and subclinical macrovascular disease after 12 months' intervention therapy with calcitriol were observed.86 patients with vitamin D insufficiency [25 (OH) D<30 ng/ml] and subclinical macrovascular disease were randomized to group A (n =44,treated with 0.5 μg/day calcitriol) or group B (n =42,blank control) for 12 months.40 patients in each group completed the follow up.After 12 months of therapy with calcitriol (0.5 μg.qd.po.),levels of high sensitive-Creactive protein,sCD36,and cIMT were significantly decreased,while 25 (OH) D and ankle brachial index were significantly increased (P<0.05) in group A,suggesting that calcitriol could improve cIMT in patients with vitamin D insufficiency and subclinical macrovascular disease.
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