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目的 探讨黏附分子CD146在颈动脉粥样硬化(CAS)斑块中的表达是否与斑块易损性相关.方法 收集40例颈动脉内膜剥脱术后的完整斑块标本及5例健康对照者颈动脉标本.40例CAS斑块根据超声影像结果分为稳定斑块组和不稳定斑块组.使用免疫组化方法检测CD146在各组中的表达强度.结果 CD146在CAS斑块中高表达,且不稳定斑块组的表达强度明显高于稳定斑块组(0.31±0.19比0.17 ±0.07,P＜0.05).CD146表达强度与斑块的坏死核心面积呈正相关(r=0.471 8,P =0.019 9),与基质金属蛋白酶-9(MMP-9)表达水平也呈正相关(r=0.535 6,P=0.000 9).结论 黏附分子CD146与CAS斑块的易损性相关.

Objective To investigate the correlation between the expression of adhesion molecule CD146 and the vulnerability of carotid atherosclerotic plaque.Methods The plaque samples were collected from 40 patients who underwent the carotid endarterectomy and were divided into the stable plaque group and the instable plaque group by ultrasound imaging.Five carotid artery samples were taken from the healthy donors as the control.Immunohistochemistry was applied to test the CD146 expression in all samples.Results Higher expression of CD146 was observed in the atherosclerotic plaques than in the healthy control.Moreover,statistical difference was found in the expression of CD146 in the plaques between the instable plaque group and the stable plaque group (0.31 ± 0.19 vs 0.17 ± 0.07,P ＜ 0.05).The expression of CD146 was positively correlated with the necrotic area (r =0.471 8,P =0.019 9) and the matrix metalloproteinase (MMP)-9 expression in the plaques (r =0.535 6,P =0.000 9).Conclusion The CD146 expression is correlated with the vulnerability of carotid atherosclerotic plaque.